Publications

Full List of Publications here

Selected Publications:

Mucin-type O-glycans regulate proteoglycan stability and chondrocyte maturation

Xiaolin Dong, Sydney Bedillion, Kaleigh. Gosnell, Peng Zhao, Amrita Basu, Kavya Suryadevara, Digantkumar Chapla, Lance Wells, Ryan J Weiss. bioRxiv. 2025.12.11.693745. doi: https://doi.org/10.64898/2025.12.11.693745

Quantitative HILIC-Q-TOF-MS analysis of glycosaminoglycans and non-reducing end carbohydrate biomarkers via glycan reductive isotopic labeling

Amrita Basu, Stephanie Archer-Hartmann, Pradeep Chopra, Mehrnoush Taherzadeh Ghahfarrokhi, Xiaolin Dong, Neil G. Patel, Yiwen Zhang, Biswa Choudhury, Kosuke Funato, Dhananjay Yellajoshyula, Geert-Jan Boons, Parastoo Azadi, Ryan J. Weiss. Analytical Chemistry. 2025 doi: https://doi.org/10.1021/acs.analchem.5c02338.

A Drosophila Model of Mucopolysaccharidosis IIIB

Bibhu Simkhada, Nestor O Nazario-Yepiz, Patrick S Freymuth, Rachel A Lyman, Vijay Shankar, Kali Wiggins, Heather Flanagan-Steet, Amrita Basu, Ryan J Weiss, Robert R H Anholt, Trudy F C Mackay. Genetics. 2024 Dec 31:iyae219. doi: 10.1093/genetics/iyae219. Epub ahead of print. PMID: 39737777.

Glycosaminoglycan-driven lipoprotein uptake protects tumors from ferroptosis

Dylan Calhoon, Lingjie Sang, Divya Bezwada, Sheng-Chieh Hsu, Feng Cai, Nathaniel Kim, Amrita Basu, Renfei Wu, Anastasia Pimentel, Bailey Brooks, Konnor La, Ana Paulina Serrano, Daniel L. Cassidy, Ling Cai, Vanina Toffessi-Tcheuyap, Mayam E. Moussa, Winnie Uritboonthai, …Ryan J. Weiss, Ralph J. DeBerardinis, Kıvanç Birsoy, Javier Garcia-Bermudez. Nature (2025). https://doi.org/10.1038/s41586-025-09162-0

**Altering heparan sulfate suppresses cell abnormalities and neuron loss in Drosophila presenilin model of Alzheimer Disease**

Nicholas Schultheis, Alyssa Connell, Alexander Kapral, Robert. Becker, Richard Mueller, Shalini Shah, Mackenzie O’Donnell, Matthew Roseman, Lindsey Swanson, Sophia DeGuara, Weihua Wang, Fei Yin, Tripti Saini, Ryan J. Weiss, Scott B. Selleck. iScience 2024. In Press. doi: https://doi.org/10.1101/2024.01.23.576895

TFCP2 is a transcriptional regulator of heparan sulfate assembly and melanoma cell growth

Basu A., Champagne, R.N., Patel, N.G., Nicholson, E.D., Weiss R.J. Journal of Biological Chemistry (2023). In press.

Glycosaminoglycan Analysis: Purification, Structural Profiling, and GAG-Protein Interactions

Basu A., Weiss R.J. Methods Mol Biol. (2023). 2597:159-176. DOI: 10.1007/978-1-0716-2835-5_13.

Spatiotemporal Diversity and Regulation of Glycosaminoglycans in Cell Homeostasis and Human Disease

Basu, A.*; Patel, N.G.*; Nicholson, E.N.; Weiss, R.J. American Journal of Physiology – Cell Physiology (2022). DOI: 10.1152/ajpcell.00085.2022.

Genome-wide Screens Uncover KDM2B as a Modifier of Protein Binding to Heparan Sulfate

Weiss, R.J.*; Spahn P.N.*; Chiang A.W.T.; Liu Q.; Li J.; Hamill K.M.; Rother S.; Clausen T.M.; Hoeksema, M.A.; Timm, B.M.; Godula, K.; Glass, C.K.; Tor, Y.; Gordts P.L.S.M.; Lewis N.E.; Esko J.D. Nature Chemical Biology (2021). https://doi.org/10.1038/s41589-021-00776-9